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Anisodamine Hydrobromide

CAS No. 55449-49-5

Anisodamine Hydrobromide( 6-Hydroxyhyoscyamine )

Catalog No. M21541 CAS No. 55449-49-5

Anisodamine Hydrobromide is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Anisodamine Hydrobromide
  • Note
    Research use only, not for human use.
  • Brief Description
    Anisodamine Hydrobromide is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.
  • Description
    Anisodamine Hydrobromide is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.
  • In Vitro
    Anisodamine hydrobromide (100 μg/mL; 20 minutes; RAW264.7 cells) pretreatment for 20 minutes before Ach results in significantly attenuated average fluorescence intensity of α-bungarotoxin binding compared with Ach alone.Anisodamine hydrobromide action might be through blockade of muscarinic receptors and thus allowing more endogenous ACh binding to the α-7nAChR.
  • In Vivo
    Anisodamine hydrobromide (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%. Animal Model:LPS-Induced Shock Mice Dosage:50 mg/kg Administration:I.p.Result:Markedly decreased the mortality to 20%.
  • Synonyms
    6-Hydroxyhyoscyamine
  • Pathway
    Angiogenesis
  • Target
    Adrenergic Receptor
  • Recptor
    α1-adrenergic receptor
  • Research Area
    Metabolic Disease
  • Indication
    Intestinal Diseases

Chemical Information

  • CAS Number
    55449-49-5
  • Formula Weight
    386.28
  • Molecular Formula
    C17H24BrNO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:77 mg/mL (199.34 mM)
  • SMILES
    Br.[H][C@@]12C[C@H](O)[C@@]([H])(C[C@H](C1)OC(=O)[C@H](CO)C1=CC=CC=C1)N2C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zhang WW et al. Differential Neuropsychopharmacological Influences of Naturally Occurring Tropane Alkaloids Anisodamine Versus Scopolamine. Neurosci Lett. 2008 Oct 10;443(3):241-5.
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